02 compared to less than of the control patients, had sufficiently severe local irritation to warrant short-term use of mild topical renova per nachnahme corticosteroids to alleviate local irritation. Tretinoin has been reported to cause severe irritation on eczematous skin and should be used only with caution in patients with this condition. Since many drugs are excreted in human milk, mitigation of fine wrinkles, mottled hyperpigmentation, and tactile roughness on the face with RENOVA may be postponed in nursing mothers until after completion of the nursing period. RENOVA should be kept out of the eyes, mouth, angles of the nose, and mucous membranes.